Перейти к основному содержанию

Consortium Psychiatricum
2024. Том 5. № 2. С. 45–61
doi:10.17816/CP15514
ISSN: 2712-7672 / 2713-2919 (online)

Гематологические коэффициенты воспаления при психических расстройствах в подростковом возрасте: обзор предметного поля Обложка

4

Попов М.Ю., Попов Ю.В., Костерин Д.Н., Лепик О.В.

PDF (ENG)
GS
Информация
в Google Scholar

Аннотация

ВВЕДЕНИЕ: Гематологические коэффициенты воспаления (ГКВ), такие как нейтрофильно-лимфоцитарное, моноцитарно-лимфоцитарное, тромбоцитарно-лимфоцитарное отношение, ассоциированы с психическими расстройствами, их тяжестью, фазой заболевания. Данные, полученные у взрослых пациентов, обобщены в систематических обзорах и метаанализах. Результаты подобных исследований у подростков не систематизированы.

ЦЕЛЬ: Обобщить результаты исследований, в которых изучали связь ГКВ с психическими расстройствами у пациентов подросткового возраста.

МЕТОДЫ: В обзор предметного поля включали исследования ГКВ у пациентов в возрасте 10–19 лет с психическими расстройствами (кроме нервной анорексии), результаты которых опубликованы на английском языке до 31 декабря 2023 года. Поиск потенциально релевантных работ проводили в базе данных MEDLINE. Отобранные работы анализировали, разделив их на 2 группы: исследования с внешним контролем (здоровые подростки) и исследования с внутренним контролем (пациенты с разной фазой психического расстройства, наличием/отсутствием аутоагрессивного поведения).

РЕЗУЛЬТАТЫ: В обзор включены результаты 11 кросс-секционных исследований. Анализ их результатов показал: 1) у подростков с психическими расстройствами (депрессия, психотические расстройства, обсессивно-компульсивное расстройство, синдром дефицита внимания и гиперактивности, расстройства, связанные с употреблением психоактивных веществ) значения ГКВ выше, чем у их сверстников без соответствующих расстройств (5 исследований); 2) значения ГКВ положительно коррелируют с выраженностью психопатологических симптомов (1 исследование); 3) высокие значения ГКВ связаны с фазой психического расстройства — манией при биполярном аффективном расстройстве (1 исследование) и обострением психоза при психотических расстройствах (1 исследование); 4) высокие значения ГКВ связаны с аутоагрессивным поведением — суицидными попытками (1 исследование) и несуицидальными самоповреждениями (1 исследование).

ЗАКЛЮЧЕНИЕ: ГКВ связаны с психическими расстройствами у подростков, их тяжестью/остротой (выраженностью симптомов, фазой заболевания, наличием аутоагрессии). Для оценки диагностической и прогностической ценности ГКВ в качестве биомаркеров психических расстройств в подростковом возрасте необходимы дальнейшие исследования более высокого методологического качества.

Общая информация

Ключевые слова: системное воспаление, психические расстройства, подростки, биомаркеры

Рубрика издания: Обзоры

Тип материала: научная статья

DOI: https://doi.org/10.17816/CP15514

Получена: 12.02.0204

Принята в печать:

Для цитаты: Попов М.Ю., Попов Ю.В., Костерин Д.Н., Лепик О.В. Гематологические коэффициенты воспаления при психических расстройствах в подростковом возрасте: обзор предметного поля Обложка // Consortium Psychiatricum. 2024. Том 5. № 2. С. 45–61. DOI: 10.17816/CP15514

Литература

  1. Minihane AM, Vinoy S, Russell WR, et al. Low-grade inflammation, diet composition and health: current research evidence and its translation. Br J Nutr. 2015;114(7):999–1012. doi: 10.1017/S0007114515002093
  2. Nogueira Silva Lima MT, Howsam M, Anton PM, et al. Effect of advanced glycation end-products and excessive calorie intake on diet-induced chronic low-grade inflammation biomarkers in murine models. Nutrients. 2021;13(9):3091. doi: 10.3390/nu13093091
  3. Gupta L, Thomas J, Ravichandran R, et al. Inflammation in cardiovascular disease: A comprehensive review of biomarkers and therapeutic targets. Cureus. 2023;15(9):e45483. doi: 10.7759/cureus.45483
  4. Nie Y, Zhou H, Wang J, Kan H. Association between systemic immune-inflammation index and diabetes: a population-based study from the NHANES. Front Endocrinol (Lausanne). 2023;14:1245199. doi: 10.3389/fendo.2023.1245199
  5. Zhao X, Li J, Li X. Association between systemic immune-inflammation index and psoriasis: a population-based study. Front Immunol. 2024;15:1305701. doi: 10.3389/fimmu.2024.1305701
  6. Wellenstein MD, Coffelt SB, Duits DEM, et al. Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis. Nature. 2019;572(7770):538–542. doi: 10.1038/s41586-019-1450-6
  7. Yacoubian TA, Fang YD, Gerstenecker A, et al. Brain and systemic inflammation in de novo Parkinson’s disease. Mov Disord. 2023;38(5):743–754. doi: 10.1002/mds.29363
  8. Butoma BG, Petrova NN, Mayorova MA. On the status of autoimmunity in the disorders of schizophrenic and depressive spectra. Vestnik of Saint Petersburg University. Medicine. 2019;14(4):284–287. doi: 10.21638/spbu11.2019.406
  9. Beurel E, Toups M, Nemeroff CB. The bidirectional relationship of depression and inflammation: Double trouble. Neuron. 2020;107(2):234–256. doi: 10.1016/j.neuron.2020.06.002
  10. Suhee FI, Shahriar M, Islam SMA, et al. Elevated serum IL-2 levels are associated with major depressive disorder: A case-control study. Clin Pathol. 2023;16:2632010X231180797. doi: 10.1177/2632010X231180797
  11. Müller N. Inflammation in schizophrenia: Pathogenetic aspects and therapeutic considerations. Schizophr Bull. 2018;44(5):973–982. doi: 10.1093/schbul/sby024
  12. Wang C, Zhu D, Zhang D, et al. Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study. BMC Psychiatry. 2023;23(1):590. doi: 10.1186/s12888-023-05081-4
  13. Michopoulos V, Powers A, Gillespie CF, et al. Inflammation in fear- and anxiety-based disorders: PTSD, GAD, and beyond. Neuropsychopharmacology. 2017;42(1):254–270. doi: 10.1038/npp.2016.146
  14. Quidé Y, Bortolasci CC, Spolding B, et al. Systemic inflammation and grey matter volume in schizophrenia and bipolar disorder: Moderation by childhood trauma severity. Prog Neuropsychopharmacol Biol Psychiatry. 2021;105:110013. doi: 10.1016/j.pnpbp.2020.110013
  15. Klyushnik TP, Zozulya SA, Oleichik IV, et al. The status of leukocyte-inhibitory system of inflammation in different age groups of patients with endogenous depression. Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(5. Vyp. 2):67–74. doi: 10.17116/jnevro202112105267
  16. Zozulya SA, Golubev SA, Tikhonov DV, et al. Immunological and clinical aspects of the long-term stages of youth schizophrenia. Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(1. Vyp. 2):5–12. doi: 10.17116/jnevro20221220125
  17. Thylur DS, Goldsmith DR. Brick by brick: Building a transdiagnostic understanding of inflammation in psychiatry. Harv Rev Psychiatry. 2022;30(1):40–53. doi: 10.1097/HRP.0000000000000326
  18. Mondelli V, Ciufolini S, Belvederi Murri M, et al. Cortisol and inflammatory biomarkers predict poor treatment response in first episode psychosis. Schizophr Bull. 2015;41(5):1162–1170. doi: 10.1093/schbul/sbv028
  19. Choi W, Stewart R, Kang HJ, et al. Interactive effects of systemic inflammation and life stressors on treatment response of depressive disorders. Brain Behav Immun. 2021;95:61–67. doi: 10.1016/j.bbi.2021.01.029
  20. Leonard BE, Schwarz M, Myint AM. The metabolic syndrome in schizophrenia: is inflammation a contributing cause? J Psychopharmacol. 2012;26(5 Suppl):33–41. doi: 10.1177/0269881111431622
  21. Rethorst CD, Bernstein I, Trivedi MH. Inflammation, obesity, and metabolic syndrome in depression: analysis of the 2009-2010 National Health and Nutrition Examination Survey (NHANES). J Clin Psychiatry. 2014;75(12):e1428–1432. doi: 10.4088/JCP.14m09009
  22. Yuan N, Chen Y, Xia Y, et al. Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses. Transl Psychiatry. 2019;9(1):233. doi: 10.1038/s41398-019-0570-y
  23. Wautier JL, Wautier MP. Pro- and anti-inflammatory prostaglandins and cytokines in humans: A Mini Review. Int J Mol Sci. 2023;24(11):9647. doi: 10.3390/ijms24119647
  24. Moosmann J, Krusemark A, Dittrich S, et al. Age- and sex-specific pediatric reference intervals for neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio. Int J Lab Hematol. 2022;44(2):296–301. doi: 10.1111/ijlh.13768
  25. Taylor JH, Bermudez-Gomez J, Zhou M, et al. Immune and oxidative stress biomarkers in pediatric psychosis and psychosis-risk: Meta-analyses and systematic review. Brain Behav Immun. 2024;117:1–11. doi: 10.1016/j.bbi.2023.12.019
  26. Ivković M, Pantović-Stefanović M, Dunjić-Kostić B, et al. Neutrophil-to-lymphocyte ratio predicting suicide risk in euthymic patients with bipolar disorder: Moderatory effect of family history. Compr Psychiatry. 2016;66:87–95. doi: 10.1016/j.comppsych.2016.01.005
  27. Nalbant A, Kaya T, Varim C, et al. Can the neutrophil/lymphocyte ratio (NLR) have a role in the diagnosis of coronavirus 2019 disease (COVID-19)? Rev Assoc Med Bras (1992). 2020;66(6):746–751. doi: 10.1590/1806-9282.66.6.746
  28. Liu D, Czigany Z, Heij LR, et al. The value of platelet-to-lymphocyte ratio as a prognostic marker in cholangiocarcinoma: A systematic review and meta-analysis. Cancers (Basel). 2022;14(2):438. doi: 10.3390/cancers14020438
  29. Adane T, Melku M, Worku YB, et al. The association between neutrophil-to-lymphocyte ratio and glycemic control in type 2 diabetes mellitus: A systematic review and meta-analysis. J Diabetes Res. 2023;2023:3117396. doi: 10.1155/2023/3117396
  30. Angkananard T, Anothaisintawee T, McEvoy M, et al. Neutrophil lymphocyte ratio and cardiovascular disease risk: A systematic review and meta-analysis. Biomed Res Int. 2018;2018:2703518. doi: 10.1155/2018/2703518
  31. Wang P, Guo X, Zhou Y, et al. Monocyte-to-high-density lipoprotein ratio and systemic inflammation response index are associated with the risk of metabolic disorders and cardiovascular diseases in general rural population. Front Endocrinol (Lausanne). 2022;13:944991. doi: 10.3389/fendo.2022.944991
  32. Gorbunova AP, Rukavishnikov GV, Kasyanov ED, Mazo GE. The role of hematological coefficients of systemic inflammation in the diagnosis and risk assessment of affective disorders. V.M. Bekhterev review of psychiatry and medical psychology. 2024;58(1):47–55. doi: 10.31363/2313-7053-2024-794
  33. Mazza MG, Lucchi S, Rossetti A, Clerici M. Neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio in non-affective psychosis: A meta-analysis and systematic review. World J Biol Psychiatry. 2020;21(5):326–338. doi: 10.1080/15622975.2019.1583371
  34. Zhu X, Zhou J, Zhu Y, et al. Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in schizophrenia. Australas Psychiatry. 2022;30(1):95–99. doi: 10.1177/10398562211022753
  35. Sugita S, Tomioka H, Mera K, et al. Neutrophil-lymphocyte ratio in patients with acute schizophrenia. Cureus. 2024;16(1):e52181. doi: 10.7759/cureus.52181
  36. Mazza MG, Lucchi S, Tringali AGM, et al. Neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in mood disorders: A meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2018;84(Pt A):229–236. doi: 10.1016/j.pnpbp.2018.03.012
  37. Cheng Y, Wang Y, Wang X, et al. Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio in depression: An updated systematic review and meta-analysis. Front Psychiatry. 2022;13:893097. doi: 10.3389/fpsyt.2022.893097
  38. Sandberg AA, Steen VM, Torsvik A. Is elevated neutrophil count and neutrophil-to-lymphocyte ratio a cause or consequence of schizophrenia? – A scoping review. Front Psychiatry. 2021;12:728990. doi: 10.3389/fpsyt.2021.728990
  39. Kessler RC, Berglund P, Demler O, et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):593–602. doi: 10.1001/archpsyc.62.6.593
  40. Solmi M, Radua J, Olivola M, et al. Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies. Mol Psychiatry. 2022;27(1):281–295. doi: 10.1038/s41380-021-01161-7
  41. Shah JL, Scott J, McGorry PD, et al. Transdiagnostic clinical staging in youth mental health: a first international consensus statement. World Psychiatry. 2020;19(2):233–242. doi: 10.1002/wps.20745
  42. Reimherr JP, McClellan JM. Diagnostic challenges in children and adolescents with psychotic disorders. J Clin Psychiatry. 2004;65 Suppl 6:5–11.
  43. Zechowski C. Diagnostic difficulties in adolescent patients –subjective psychiatrist-side factors. Psychiatr Pol. 2012;46(2):241–247.
  44. Copeland WE, Adair CE, Smetanin P, et al. Diagnostic transitions from childhood to adolescence to early adulthood. J Child Psychol Psychiatry. 2013;54(7):791–799. doi: 10.1111/jcpp.12062
  45. Lawson EA, Miller KK, Mathur VA, et al. Hormonal and nutritional effects on cardiovascular risk markers in young women. J Clin Endocrinol Metab. 200;92(8):3089–3094. doi: 10.1210/jc.2007-0364
  46. Ferencova N, Visnovcova Z, Ondrejka I, et al. Peripheral inflammatory markers in autism spectrum disorder and attention deficit/hyperactivity disorder at adolescent age. Int J Mol Sci. 2023;24(14):11710. doi: 10.3390/ijms241411710
  47. Önder A, Gizli Çoban Ö, Sürer Adanır A. Elevated neutrophil-to-lymphocyte ratio in children and adolescents with attention-deficit/hyperactivity disorder. Int J Psychiatry Clin Pract. 2021;25(1):43–48. doi: 10.1080/13651501.2020.1804940
  48. Karatoprak S, Uzun N, Akıncı MA, Dönmez YE. Neutrophil-lymphocyte and platelet-lymphocyte ratios among adolescents with substance use disorder: A preliminary study. Clin Psychopharmacol Neurosci. 2021;19(4):669–676. doi: 10.9758/cpn.2021.19.4.669
  49. Özyurt G, Binici NC. The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in adolescent obsessive-compulsive disorder: Does comorbid anxiety disorder affect inflammatory response? Psychiatry Res. 2019;272:311–315. doi: 10.1016/j.psychres.2018.12.131
  50. Ceylan MF, Tural Hesapcioglu S, Kasak M, et al. Increased prolidase activity and high blood monocyte counts in pediatric bipolar disorder. Psychiatry Res. 2019;271:360–364. doi: 10.1016/j.psychres.2018.11.066
  51. Özyurt G, Binici NC. Increased neutrophil-lymphocyte ratios in depressive adolescents is correlated with the severity of depression. Psychiatry Res. 2018;268:426–431. doi: 10.1016/j.psychres.2018.08.007
  52. Binici NC, Alşen Güney S, İnal Emiroğlu FN. Neutrophil-lymphocyte and platelet-lymphocyte ratios among adolescents with bipolar disorder: A preliminary study. Psychiatry Res. 2018;269:178–182. doi: 10.1016/j.psychres.2018.08.065
  53. Cui S, Liu Z, Liu Y, et al. Correlation between systemic immune-inflammation index and suicide attempts in children and adolescents with first-episode, drug-naïve major depressive disorder during the COVID-19 pandemic. J Inflamm Res. 2023;16:4451–4460. doi: 10.2147/JIR.S433397
  54. Zheng Q, Liu J, Ji Y, et al. Elevated levels of monocyte-lymphocyte ratio and platelet-lymphocyte ratio in adolescents with non-suicidal self-injury. BMC Psychiatry. 2022;22(1):618. doi: 10.1186/s12888-022-04260-z
  55. Drapisz A, Avrahami M, Ben Dor DH, et al. Association between neutrophil to lymphocyte ratio and mood polarity in adolescents admitted to an inpatient psychiatric ward. Int Clin Psychopharmacol. 2022;37(6):242–246. doi: 10.1097/YIC.0000000000000412
  56. Bustan Y, Drapisz A, Ben Dor DH, et al. Elevated neutrophil to lymphocyte ratio in non-affective psychotic adolescent inpatients: Evidence for early association between inflammation and psychosis. Psychiatry Res. 2018;262:149–153. doi: 10.1016/j.psychres.2018.02.002
  57. Tricco AC, Lillie E, Zarin W, et al. PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation. Ann Intern Med. 2018;169(7):467–473. doi: 10.7326/M18-0850
  58. Önder A, Adanir AS, Çoban ÖG, et al. Elevated neutrophil/lymphocyte ratio in adolescents with early-onset schizophrenia. Neurochem J. 2020;14(4):444–448. doi: 10.1134/s1819712420330016
  59. Gędek A, Modrzejewski S, Gędek M, et al. Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and monocyte to lymphocyte ratio in ADHD: a systematic review and meta-analysis. Front Psychiatry. 2023;14:1258868. doi: 10.3389/fpsyt.2023.1258868
  60. Su M, Ouyang X, Song Y. Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and monocyte to lymphocyte ratio in depression: A meta-analysis. J Affect Disord. 2022;308:375–383. doi: 10.1016/j.jad.2022.04.038
  61. Velasco A, Lengvenyte A, Rodriguez-Revuelta J, et al. Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio in depressed patients with suicidal behavior: A systematic review. Eur Psychiatry. 2023:1–25. doi: 10.1192/j.eurpsy.2023.18
  62. Herdi O, Sayar-Akaslan D, İlhan RS, et al. Associations between subclinical inflammatory markers and OCD: A retrospective study. Psychiatry Res. 2020;290:113065. doi: 10.1016/j.psychres.2020.113065
  63. Sekeryapan Gediz B, Ozturk M, Kilinc Hekimsoy H, et al. Choroidal vascularity index as a potential inflammatory biomarker for obsessive compulsive disorder. Ocul Immunol Inflamm. 2022;30(2):428–432. doi: 10.1080/09273948.2020.1800052
  64. Guzel D, Yazici AB, Yazici E, Erol A. Evaluation of immunomodulatory and hematologic cell outcome in heroin/opioid addicts. J Addict. 2018;2018:2036145. doi: 10.1155/2018/2036145
  65. Quraishi R, Kathiresan P, Verma K, et al. Effect of chronic opioid use on the hematological and inflammatory markers: A retrospective study from North India. Indian J Psychiatry. 2022;64(3):252–256. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_751_21
  66. Tural Hesapcioglu S, Kasak M, Cıtak Kurt AN, Ceylan MF. High monocyte level and low lymphocyte to monocyte ratio in autism spectrum disorders. Int J Dev Disabil. 2017;65(2):73–81. doi: 10.1080/20473869.2017.1371369
  67. Esnafoglu E, Subaşı B. Association of low 25-OH-vitamin D levels and peripheral inflammatory markers in patients with autism spectrum disorder: Vitamin D and inflammation in autism. Psychiatry Res. 2022;316:114735. doi: 10.1016/j.psychres.2022.114735
  68. Ellul P, Maruani A, Peyre H, et al. Abnormal neutrophil-to-lymphocyte ratio in children with autism spectrum disorder and history of maternal immune activation. Sci Rep. 2023;13(1):22424. doi: 10.1038/s41598-023-49789-5
  69. Kayhan F, Gündüz Ş, Ersoy SA, et al. Relationships of neutrophil-lymphocyte and platelet-lymphocyte ratios with the severity of major depression. Psychiatry Res. 2017;247:332–335. doi: 10.1016/j.psychres.2016.11.016
  70. Shan M, Yang Z, Sun Z, et al. Association between platelet to lymphocyte ratio and depression and symptom severity among adults in the United States: A cross-sectional study. Heliyon. 2023;9(9):e20127. doi: 10.1016/j.heliyon.2023.e20127
  71. Zhou X, Wang X, Li R, et al. Neutrophil-to-lymphocyte ratio is independently associated with severe psychopathology in schizophrenia and is changed by antipsychotic administration: A large-scale cross-sectional retrospective study. Front Psychiatry. 2020;11:581061. doi: 10.3389/fpsyt.2020.581061
  72. Abdel Samei AM, Mahmoud DAM, Salem Boshra B, Abd El Moneam MHE. The interplay between blood inflammatory markers, symptom domains, and severity of ADHD disorder in children. J Atten Disord. 2024;28(1):66–76. doi: 10.1177/10870547231197213
  73. Mazza MG, Tringali AGM, Rossetti A, et al. Cross-sectional study of neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in mood disorders. Gen Hosp Psychiatry. 2019;58:7–12. doi: 10.1016/j.genhosppsych.2019.02.003
  74. Fusar-Poli L, Natale A, Amerio A, et al. Neutrophil-to-lymphocyte, platelet-to-lymphocyte and monocyte-to-lymphocyte ratio in bipolar disorder. Brain Sci. 2021;11(1):58. doi: 10.3390/brainsci11010058
  75. Özdin S, Böke Ö. Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in different stages of schizophrenia. Psychiatry Res. 2019;271:131–135. doi: 10.1016/j.psychres.2018.11.043
  76. Ucuz İ, Kayhan Tetik B. Can suicide behavior and seasonality of suicide be predicted from inflammatory parameters in adolescents? Med Hypotheses. 2020;143:110061. doi: 10.1016/j.mehy.2020.110061
  77. Puangsri P, Ninla-Aesong P. Potential usefulness of complete blood count parameters and inflammatory ratios as simple biomarkers of depression and suicide risk in drug-naive, adolescents with major depressive disorder. Psychiatry Res. 2021;305:114216. doi: 10.1016/j.psychres.2021.114216
  78. Kumar K, Srivastava S, Sharma B, et al. Comparison between inflammatory biomarkers (high-sensitivity C-reactive protein and neutrophil-lymphocyte ratio) and psychological morbidity in suicide attempt survivors brought to medicine emergency. Cureus. 2021;13(8):e17459. doi: 10.7759/cureus.17459
  79. Arango-Dávila CA, Rincón-Hoyos HG. Depressive disorder, anxiety disorder and chronic pain: Multiple manifestations of a common clinical and pathophysiological core. Rev Colomb Psiquiatr (Engl Ed). 2018;47(1):46–55. doi: 10.1016/j.rcp.2016.10.007
  80. Perry BI, Upthegrove R, Kappelmann N, et al. Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: A bi-directional two-sample mendelian randomization study. Brain Behav Immun. 2021;97:176–185. doi: 10.1016/j.bbi.2021.07.009
  81. Saccaro LF, Gasparini S, Rutigliano G. Applications of Mendelian randomization in psychiatry: a comprehensive systematic review. Psychiatr Genet. 2022;32(6):199–213. doi: 10.1097/YPG.0000000000000327
  82. Brinn A, Stone J. Neutrophil-lymphocyte ratio across psychiatric diagnoses: a cross-sectional study using electronic health records. BMJ Open. 2020;10(7):e036859. doi: 10.1136/bmjopen-2020-036859
  83. Bauer ME, Teixeira AL. Inflammation in psychiatric disorders: what comes first? Ann N Y Acad Sci. 2019;1437(1):57–67. doi: 10.1111/nyas.13712
  84. Khalfallah O, Barbosa S, Martinuzzi E, et al. Monitoring inflammation in psychiatry: Caveats and advice. Eur Neuropsychopharmacol. 2022;54:126–135. doi: 10.1016/j.euroneuro.2021.09.003
  85. Adzic M, Brkic Z, Mitic M, et al. Therapeutic strategies for treatment of inflammation-related depression. Curr Neuropharmacol. 2018;16(2):176–209. doi: 10.2174/1570159X15666170828163048
  86. Decker K, Murata S, Baig N, et al. Utilizing the systemic immune-inflammation index and blood-based biomarkers in association with treatment responsiveness amongst patients with treatment-resistant bipolar depression. J Pers Med. 2023;13(8):1245. doi: 10.3390/jpm13081245
  87. Murata S, Baig N, Decker K, Halaris A. Systemic inflammatory response index (SIRI) at baseline predicts clinical response for a subset of treatment-resistant bipolar depressed patients. J Pers Med. 2023;13(9):1408. doi: 10.3390/jpm13091408
  88. Vos CF, Birkenhäger TK, Nolen WA, et al. Association of the neutrophil to lymphocyte ratio and white blood cell count with response to pharmacotherapy in unipolar psychotic depression: An exploratory analysis. Brain Behav Immun Health. 2021;16:100319. doi: 10.1016/j.bbih.2021.100319
  89. Llorca-Bofí V, Palacios-Garrán R, Rey Routo D, et al. High neutrophil-lymphocyte ratio upon admission is associated with better response in psychotic depression. J Psychiatr Res. 2021;143:38–42. doi: 10.1016/j.jpsychires.2021.08.021
  90. Labonté C, Zhand N, Park A, Harvey PD. Complete blood count inflammatory markers in treatment-resistant schizophrenia: Evidence of association between treatment responsiveness and levels of inflammation. Psychiatry Res. 2022;308:114382. doi: 10.1016/j.psychres.2021.114382
  91. Llorca-Bofí V, Bioque M, Madero S, et al. Blood cell count ratios at baseline are associated with initial clinical response to clozapine in treatment-resistant, clozapine-naïve, schizophrenia-spectrum disorder. Pharmacopsychiatry. 2024. doi: 10.1055/a-2290-6386
  92. Ninla-Aesong P, Puangsri P, Kietdumrongwong P, et al. Being overweight and obese increases suicide risk, the severity of depression, and the inflammatory response in adolescents with major depressive disorders. Front Immunol. 2023;14:1197775. doi: 10.3389/fimmu.2023.1197775
  93. Özdin S, Sarisoy G, Böke Ö. A comparison of the neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in schizophrenia and bipolar disorder patients — a retrospective file review. Nord J Psychiatry. 2017;71(7):509–512. doi: 10.1080/08039488.2017.1340517
  94. Bulut NS, Yorguner N, Çarkaxhiu Bulut G. The severity of inflammation in major neuropsychiatric disorders: comparison of neutrophil-lymphocyte and platelet-lymphocyte ratios between schizophrenia, bipolar mania, bipolar depression, major depressive disorder, and obsessive compulsive disorder. Nord J Psychiatry. 2021;75(8):624–632. doi: 10.1080/08039488.2021.1919201
  95. Wei Y, Feng J, Ma J, et al. Characteristics of platelet-associated parameters and their predictive values in Chinese patients with affective disorders. BMC Psychiatry. 2022;22(1):150. doi: 10.1186/s12888-022-03775-9
  96. Vancampfort D, Stubbs B, Mitchell AJ, et al. Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: A systematic review and meta-analysis. World Psychiatry. 2015;14(3):339–347. doi: 10.1002/wps.20252
  97. Penninx BWJH, Lange SMM. Metabolic syndrome in psychiatric patients: Overview, mechanisms, and implications. Dialogues Clin Neurosci. 2018;20(1):63–73. doi: 10.31887/DCNS.2018.20.1/bpenninx
  98. Silveira Rossi JL, Barbalho SM, Reverete de Araujo R, et al. Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors. Diabetes Metab Res Rev. 2022;38(3):e3502. doi: 10.1002/dmrr.3502
  99. Chakraborty S, Verma A, Garg R, et al. Cardiometabolic risk factors associated with type 2 diabetes mellitus: A mechanistic insight. Clin Med Insights Endocrinol Diabetes. 2023;16:11795514231220780. doi: 10.1177/11795514231220780
  100. Suggett J, Foster K, Lakra V, et al. Natural cause mortality of mental health consumers: A 10-year retrospective cohort study. Int J Ment Health Nurs. 2021;30(2):390–400. doi: 10.1111/inm.12797
  101. Minhas S, Patel JR, Malik M, et al. Mind-body connection: Cardiovascular sequelae of psychiatric illness. Curr Probl Cardiol. 2022;47(10):100959. doi: 10.1016/j.cpcardiol.2021.100959

Информация об авторах

Попов Михаил Юрьевич, доктор медицинских наук, ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России, Санкт-Петербург, Россия, ORCID: https://orcid.org/0000-0002-7905-4583, e-mail: popovmikhail@mail.ru

Попов Юрий Васильевич, доктор медицинских наук, ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России, Профессор, главный научный сотрудник отделения лечения психических расстройств у подростков и молодых взрослых, Санкт-Петербург, Россия, ORCID: https://orcid.org/0000-0003-1644-8080, e-mail: popov62@yandex.ru

Костерин Дмитрий Николаевич, Научный сотрудник Врач психиатр, Отделение лечения психических расстройств у лиц молодого возраста, ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России, Санкт-Петербург, Россия, ORCID: https://orcid.org/0000-0003-3677-2144

Лепик Ольга Витальевна, ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России, Санкт-Петербург, Россия, ORCID: https://orcid.org/0000-0001-9516-4427, e-mail: ovlepik@gmail.com

Метрики

Просмотров

Всего: 27
В прошлом месяце: 18
В текущем месяце: 5

Скачиваний

Всего: 4
В прошлом месяце: 2
В текущем месяце: 1