Vestnik of Saint Petersburg University. Psychology
2018. Vol. 8, no. 1, 83–104
ISSN: 2658-3607 / 2658-6010 (online)
Features of Physiological Mechanisms of Cognitive Functions in Patients with Schizophrenia Using Different Types of Pharmacotherapy
Abstract
The article describes results of the study of the neurophysiological mechanisms of cognitive functions associated with the parameters of various cognitive styles. Subjects included schizophreniс patients with paranoid attacks and healthy people. Subjects also made up two groups based on the intake of various types of neuroleptics. Methods: psychological techniques for measuring cognitive styles, SANS. The ERP to different sequences, consisting of standard and deviant stimuli. Results: We have found changes in the neurophysiological mechanisms of cognitive functions depending on cognitive styles and the intake of various types of neuroleptics. Neurophysiological mechanisms of cognitive functions are associated with the short-term memory system and the work of the hippocampal structures that provide the potential of neuronal synapses.
General Information
Keywords: prediction, cognitive styles, EEG, event related potentials, pharmacotherapy, typical antipsychotics, atypical antipsychotics, implicit learning, explicit learning, neuroimaging
Journal rubric: Clinical Psychology and Psychophysiology
Article type: scientific article
For citation: Gorbunov J.A., Chepikova K.A., Gaevsky A.A., Yanichev D.P. Features of Physiological Mechanisms of Cognitive Functions in Patients with Schizophrenia Using Different Types of Pharmacotherapy. Vestnik of Saint Petersburg University. Psychology, 2018. Vol. 8, no. 1, pp. 83–104. (In Russ., аbstr. in Engl.)
References
Anohin P.K. Ocherki po fiziologii funktsional’nykh sistem [ Essays on the Physiology of Functional Systems]. Moscow, Meditsina Publ., 1975. 448 p. (In Russian)
Friston K. A theory of cortical responses. Philosophical transactions of the Royal Society B: Biological sciences, 2005, vol. 360, no. 1456, pp. 815–836.
Winkler I. Interpreting the mismatch negativity. Journal of Psychophysiology, 2007, vol. 21, no. 3, pp. 147–163.
Baldeweg T. ERP repetition effects and mismatch negativity generation: A predictive coding perspective. Journal of Psychophysiology, 2007, vol. 21, no. 3–4, pp. 204–213.
http://doi.org/10.1027/02698803.21.34.204”
target=”_blank”>http://doi.org/10.1027/02698803.21.34.204
Gluck M.A. Behavioral and neural correlates of error correction in classical conditioning and human category learning. Memory and Mind: A Festschrift for Gordon H.Bower. Mahwah; New Jersey; London, Lawrence Erlbaum Associates, Publishers, 2008, pp. 281–305.
Gluck M.A. et al. Cerebellar substrates for error correction in motor conditioning. Neurobiology of learning and memory, 2001, vol. 76, no. 3, pp. 314–341.
Ford J.M. et al. ERPs in schizophrenia: effects of antipsychotic medication. Biological psychiatry, 1994, vol. 36, no. 3, pp. 153–170.
Ford J.M. Schizophrenia: the broken P300 and beyond. Psychophysiology, 1999, vol. 36, no. 6, pp. 667– 682.
Hirayasu Y. et al. Auditory mismatch negativity in schizophrenia: topographic evaluation with a high‐ density recording montage. American Journal of Psychiatry, 1998, vol. 155, no. 9, pp. 1281–1284.
Javitt D.C., Shelley A.M., Ritter W. Associated deficits in mismatch negativity generation and tone matching in schizophrenia. Clinical Neurophysiology, 2000, vol. 111, no. 10, pp. 1733–1737.
Jessen F. et al. Amplitude reduction of the mismatch negativity in first‐degree relatives of patients with schizophrenia. Neuroscience letters, 2001, vol. 309, no. 3, pp. 185–188.
Juckel G. et al. Residual symptoms and P300 in schizophrenic outpatients, Psychiatry research, 1996, vol. 65, no. 1, pp. 23–32.
Kasai K. et al. Do high or low doses of anxiolytics and hypnotics affect mismatch negativity in schizophrenic subjects? An EEG and MEG study. Clinical Neurophysiology, 2002, vol. 113, no. 1, pp. 141–150.
Kawakubo Y. et al. Phonetic mismatch negativity predicts social skills acquisition in schizophrenia. Psychiatry research, 2007, vol. 152, no. 2, pp. 261–265.
Kessier C., Steinberg A. Evoked potential variation in schizophrenic subgroups. Biological psychiatry, 1989, vol. 26, no. 4, pp. 372–380.
Korostenskaja M. et al. Effects of olanzapine on auditory P300 and mismatch negativity (MMN) in schizophrenia spectrum disorders. Progress in Neuro‐Psychopharmacology and Biological Psychiatry, 2005, vol. 29, no. 4, pp. 543–548.
Mathalon D.H., Ford J.M., Pfefferbaum A. Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study. Biological psychiatry, 2000, vol. 47, no. 5, pp. 434–449.
Näätänen R. et al. The mismatch negativity (MMN)–a unique window to disturbed central auditory processing in ageing and different clinical conditions. Clinical Neurophysiology, 2012, vol. 123, no. 3, pp. 424–458.
Wynn J.K. et al. Mismatch negativity, social cognition, and functioning in schizophrenia patients. Biological psychiatry, 2010, vol. 67, no. 10, pp. 940–947.
Holodnaya M.A. Kognitivnye stili. O prirode individual’nogo uma [ Cognitive styles. About the nature of the individual mind]. 2nd ed. St. Petersburg, Peter Publ., 2004. 384 p. (In Russian)
Kolga V.A. Differentsial’no-psikhologicheskoe issledovanie kognitivnogo stilia i obuchaemosti. Dis. kand. psikhol. nauk [ Differential-psychological study of cognitive style and learning. Diss. ]. Leningrad, LGU Press, 1976. (In Russian)
Pascual-Marqui R.D., Michel C.M., Lehmann D. Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. International Journal of psychophysiology, 1994, vol. 18, no. 1, pp. 49–65.
Volpe U. et al. The cortical generators of P3a and P3b: a LORETA study. Brain research bulletin, 2007, vol. 73, no. 4, pp. 220–230.
Goldstein K., Spencer M., Donchin E. The influence of stimulus deviance and novelty on the P300 and novelty P3. Psychophysiology, 2002, vol. 39, pp. 781–790.
Patel S.H., Azzam P.N. Characterization of N200 and P300: selected studies of the event-related potential, Int. J. Med. Sci. , 2005, vol. 2, pp. 147–154.
Chepikova K.A., Mikushkina L.V., Gorbunov I.A. [ Peculiarities of psychophysiological mechanisms of predicting sequences of events in schizophrenia]. Aktual’nye napravleniia nauchnykh issledovanii: ot teorii k praktike: mat-ly V Mezhdunar. nauch.-prakt. konf. (Cheboksary, 26 iiunia 2015 g.) [ Actual directions of scientific research: from theory to practice: materials V Intern. scientific-practical. Conf. (Cheboksary, June 26, 2015)]. Cheboksary, CNS «Interaktiv plyus», 2015, no. 3 (5), pp. 232–245. (In Russian)
Gorbunov I.A., Chepikova K.A., Mikushkina L.V. Osobennosti psikhofiziologicheskikh mekhanizmov prognozirovaniia posledovatel’nostei sobytii pri shizofrenii [Features of psychophysiological mechanisms of predicting sequences of events in schizophrenia]. The seventh international conference on cognitive science, 2016, pp. 236–238. (In Russian)
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