Clinical Psychology and Special Education
2024. Vol. 13, no. 4, 5–28
doi:10.17759/cpse.2024130401
ISSN: 2304-0394 (online)
Brain Aging: Key Theories and Neurophysiological Insights
Abstract
In recent years, the problem of brain aging is becoming more and more relevant due to the increasing proportion of elderly people in the population. One of the key issues in this area is the study of the effect of aging on cognitive functions and brain activity, since these functions play an important role in everyday life and determine a person’s ability to lead a full, independent life and adapt to a changing environment. The aim of this article was to review foreign literature concerning the main theories of cognitive aging such as the frontal cortex aging theory, compensatory theories, reserve theory, sensory deprivation theory, information processing speed reduction theory and inhibitory influence deficit theory. Particular attention is paid to the neurophysiological aspects of aging. The literature search was carried out by keywords using the Google Scholar and PubMed databases. The reviewed results of neurocognitive studies allow us to identify structural and functional changes in the brain during aging, which can help clinical specialists differentiate “normal” aging from possible signs of brain diseases and develop a more individual approach if necessary to correct cognitive impairment.
General Information
Keywords: cognitive functions, theories of cognitive aging, neurocognitive research, neurophysiology of aging
Journal rubric: Theoretical Research
Article type: scientific article
DOI: https://doi.org/10.17759/cpse.2024130401
Funding. The reported study was carried out with the support of the Moscow State Psychological and Pedagogical University
Received: 03.05.2024
Accepted:
For citation: Tretyakova V.D., Pultsina K.I. Brain Aging: Key Theories and Neurophysiological Insights [Elektronnyi resurs]. Klinicheskaia i spetsial'naia psikhologiia = Clinical Psychology and Special Education, 2024. Vol. 13, no. 4, pp. 5–28. DOI: 10.17759/cpse.2024130401. (In Russ., аbstr. in Engl.)
References
- Albinet C.T., Boucard G., Bouquet C.A., Audiffren M. Processing speed and executive functions in cognitive aging: how to disentangle their mutual relationship? Brain and Cognition, Vol. 79, no. 1, pp. 1–11. doi: 10.1016/j.bandc.2012.02.001
- Alexander G.E., Furey M. L., Grady C.L., et al. Association of premorbid intellectual function with cerebral metabolism in Alzheimer’s disease: Implications for the cognitive reserve hypothesis. American Journal of Psychiatry, 1997. Vol. 154, no. 2, pp. 165–172. DOI: 10.1176/ajp.154.2.165
- Amieva H., Mokri H., Le Goff M. et al. Compensatory mechanisms in higher-educated subjects with Alzheimer’s disease: a study of 20 years of cognitive decline. Brain, 2014. Vol. 137, no. 4, pp. 1167–1175. DOI: 10.1093/brain/awu035
- Anglade C., Thiel A., Ansaldo A.I. The complementary role of the cerebral hemispheres in recovery from aphasia after stroke: A critical review of literature. Brain Injury, 2014. Vol. 28, no. 2, pp. 138–145. DOI: 10.3109/02699052.2013.859734
- Attems J., Walke L., Jellinger K.A. Olfaction and Aging: A Mini-Review. Gerontology, 2015. Vol. 61, no. 6. Р. 485–490. DOI: 10.1159/000381619
- Azari N.P., Rapoport S.I., Salerno J.A. et al. Interregional correlations of resting cerebral glucose metabolism in old and young women. Brain Research, 1992. Vol. 589, no. 2, pp. 279–290. DOI: 10.1016/0006-8993(92)91288-p
- Baltes P.B., Lindenberger U. Emergence of a powerful connection between sensory and cognitive functions across the adult life span: A new window to the study of cognitive aging? Psychology and Aging, 1997. Vol. 12, no. 1, pp. 12–21. DOI: 10.1037/0882-7974.12.1.12
- Bartoshuk L.M., Catalanotto F., Hoffman H. et al. Taste damage (otitis media, tonsillectomy and head and neck cancer), oral sensations and BMI. Physiology & Behavior, 2012. Vol. 107, no. 4, pp. 516–526. DOI: 10.1016/j.physbeh.2012.06.013
- Bauer E., Gebhardt H., Gruppe H., et al. Altered negative priming in older subjects: first evidence from behavioral and neural level. Frontiers in Human Neuroscience, 2012. Vol. 6. Art. 270. DOI: 10.3389/fnhum.2012.00270
- Borsa V.M., Perani D., Della Rosa P.A. et al. Bilingualism and healthy aging: Aging effects andneural maintenance. Neuropsychologia, 2018. Vol. 111, pp. 51–61. doi:1016/j.neuropsychologia.2018.01.012
- Brown A.C., Corner M., Crewther D.P., Crewther S.G. Age related decline in cortical multifocal flash VEP: latency increases shown to be predominately magnocellular. Frontiers in Aging Neuroscience, 2019. Vol. 18, no. 10, pp. 430. DOI: 10.3389/fnagi.2018.00430
- Bunzeck N., Steiger T., Krämer U. et al. Trajectories and contributing factors of neural compensation in healthy and pathological aging. Neuroscience and Biobehavioral Reviews, 2024. Vol. 156. Art. 105489. DOI: 10.1016/j.neubiorev.2023.105489
- Cabeza R. Hemispheric asymmetry reduction in older adults: the HAROLD model. Psychology and Aging, 2002. Vol. 17, no. 1, pp. 85–100. DOI: 10.1037//0882-7974.17.1.85
- Chan D., Shafto M., Kievit R. et al. Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation and late-life activities. Neurobiology of Aging, 2018. Vol. 70, pp. 180–183. DOI: 10.1016/j.neurobiolaging.2018.06.012
- Churnin I., Qazi J., Fermin C.R. et al. Association between olfactory and gustatory dysfunction and cognition in older adults. American Journal of Rhinology & Allergy, 2019. Vol. 33, no. 2, pp. 170–177. DOI: 10.1177/1945892418824451
- Daselaar S., Fleck M., Dobbins I. et al. Effects of healthy aging on hippocampal and rhinal memory functions: an event-related fMRI study. Cerebral Cortex, 2006. Vol. 16, no. 12, pp. 1771–1782. DOI: 10.1093/cercor/bhj112
- Dash S., Clarke G., Berk M., Jacka F.N. The gut microbiome and diet in psychiatry: focus on depression. Current Opinion in Psychiatry, 2015. Vol. 28, no. 1, pp. 1–6. DOI: 10.1097/YCO.0000000000000117
- Davis S. W., Dennis N. A., Daselaar S. M. et al. Que PASA? The posterior-anterior shift in aging. Cerebral Cortex, 2008. Vol. 18, no. 5, pp. 1201–1209. DOI: 10.1093/cercor/bhm155
- De Beni R., Palladino P. Decline in working memory updating through ageing: intrusion error analyses. Memory, 2004. Vol. 12, no. 1, pp. 75–89. DOI: 10.1080/09658210244000568
- Dekaban A. S., Sadowsky D. Changes in brain weights during the span of human life: relation of brain weights to body heights and body weights. Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society, 1978. Vol. 4, no. 4, pp. 345–356. DOI: 10.1002/ana.410040410
- De Lange A.G., Kaufmann T., Quintana D.S. et al. Prominent health problems, socioeconomic deprivation, and higher brain age in lonely and isolated individuals: A population-based study. Behavioural Brain Research, 2021. Vol. 24, no. 414, art. 113510. DOI: 10.1016/j.bbr.2021.11351
- Desai R., Tailor A., Bhatt T. Effects of yoga on brain waves and structural activation: A review. Complementary Therapies in Clinical Practice, 2015. Vol. 21, no. 2, pp. 112–118. DOI: 10.1016/j.ctcp.2015.02.002
- Egerton A., Mehta M.A., Montgomery A.J. et al. The dopaminergic basis of human behaviors: A review of molecular imaging studies. Neuroscience & Biobehavioral Reviews, 2009. Vol. 33, no. 7, pp. 1109–1132. DOI: 10.1016/j.neubiorev.2009.05.005
- Eggenberger P., Theill N., Holenstein S. et al. Multicomponent physical exercise with simultaneous cognitive training to enhance dual-task walking of older adults: a secondary analysis of a 6-month randomized controlled trial with 1-year follow-up. Clinical Interventions in Aging, 2015. Vol. 28, no. 10, pp. 1711–1732. DOI: 10.2147/CIA.S91997
- Erickson K.I., Leckie R.L., Weinstein A.M. Physical activity, fitness, and gray matter volume. Neurobiology of Aging, 2014. Vol. 35. Suppl. 2, pp. S20–S28. DOI:1016/j.neurobiolaging.2014.03.034
- Erraji-Benchekroun L., Underwood M.D., Arango V. et al. Molecular aging in human prefrontal cortex is selective and continuous throughout adult life. Biological Psychiatry, 2005. Vol. 57, no. 5, pp. 549–558. DOI: 10.1016/j.biopsych.2004.10.034
- Ertek S., Cicero A. Impact of physical activity on inflammation: effects on cardiovascular disease risk and other inflammatory conditions. Archives of Medical Science, 2012. Vol. 8, no. 5, pp. 794–804. DOI: 10.5114/aoms.2012.31614
- Frings C., Schneide, K.K., Fox E. The negative priming paradigm: An update and implications for selective attention. Psychonomic Bulletin & Review, 2015. Vol. 22, pp. 1577–1597. DOI: 10.3758/s13423-015-0841-4
- Fröhlich A., Gerstner N., Gagliardi M. et al. Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease. Nature Neuroscience, 2024. Vol. 10, pp. 2021–2032. DOI: 10.1038/s41593-024-01742-z
- Gopinath B., Sue C.M., Kifley A., Mitchell P. The association between olfactory impairment and total mortality in older adults. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 2012. Vol. 67, no. 2, pp. 204–209. DOI: 10.1093/gerona/glr165
- Greenwood P.M. The frontal aging hypothesis evaluated. Journal of the International Neuropsychological Society: JINS, 2000. Vol. 6, no. 6, pp. 705–726. DOI:1017/s1355617700666092
- Greenwood P.M., Parasuraman R. The scaling of spatial attention in visual search and its modification in healthy aging. Perception & Psychophysics, 2004. Vol. 66, no. 1, pp. 3–22. DOI: 10.3758/BF03194857
- Guerreiro M.J., Eck J., Moerel M. et al. Top-down modulation of visual and auditory cortical processing in aging. Behavioural Brain Research, 2015. Vol. 278, no. 1, pp. 226–234 DOI: 10.1016/j.bbr.2014.09.049
- Habich A., Garcia-Cabello E., Abbatantuono C. et al. The effect of cognitive reserve on the cognitive connectome in healthy ageing. Geroscience, 2024. Advance online publication. DOI: 10.1007/s11357-024-01328-4
- Haug H., Eggers R. Morphometry of the human cortex cerebri and corpus striatum during aging. Neurobiology of Aging, 1991. Vol. 12, no. 4, pp. 336–355. DOI:10.1016/0197-4580(91)90013-a
- Hoffman H.J., Ishii E.K., MacTurk R.H. Age-related changes in the prevalence of smell/taste problems among the United States adult population. Results of the 1994 disability supplement to the National Health Interview Survey (NHIS). Annals of the New York Academy of Sciences, 1998. Vol. 855, pp. 716–722. DOI: 10.1111/j.1749-6632.1998.tb10650.x
- Honda M., Nagamine T., Fukuyama H. et al. Movement-related cortical potentials and regional cerebral blood flow in patients with stroke after motor recovery. Journal of the Neurological Sciences, 1997. Vol. 146, no. 2, pp. 117–126. DOI: 10.1016/s0022-510x(96)00291-2
- Houghton G., Tipper S.P. A model of inhibitory mechanisms in selective attention. In: Inhibitory Mechanisms in Attention Memory and Language. Academic Press: Florida, 1994. Pp. 53–112.
- Hsieh S., Yang M., Yao Z. Age differences in the functional organization of the prefrontal cortex: analyses of competing hypotheses. Cerebral Cortex, 2023. Vol. 33, no. 7, pp. 4040–4055. DOI: 10.1093/cercor/bhac325
- Humes L.E., Busey T.A., Craig J., Kewley-Port D. The effects of age on sensory thresholds and temporal gap detection in hearing, vision, and touch. Attention, Perception, & Psychophysics, 2009. Vol. 71, pp. 860–871. DOI: 10.3758/APP.71.4.860
- Jackson J.H. The Croonian lectures on evolution and dissolution of the nervous system. British Medical Journal, 1884. Vol. 1215, no. 1, pp. 703–707.
- Jensen A.R., Rohwer Jr W.D. The Stroop color-word test: a review. Acta Psychologica, 1966. Vol. 25, pp. 36–93. DOI: 10.1016/0001-6918(66)90004-7
- Jones R.N., Manly J., Glymour M.M. et al. Conceptual and measurement challenges in research on cognitive reserve. Journal of the International Neuropsychological Society, 2011. Vol. 17, pp. 593–601. DOI: 10.1017/S1355617710001748
- Kano M., Shimizu Y., Okayama K., Kikuchi M. Quantitative study of ageing epiglottal taste buds in humans. Gerodontology, 2007. Vol. 24, no. 3, pp. 169–172. DOI: 10.1111/j.1741-2358.2007.00165.x
- Kao W.T.K., Parnes L.S., Chole R.A. Otoconia and otolithic membrane fragments within the posterior semicircular canal in benign paroxysmal positional vertigo. The Laryngoscope, 2017. Vol. 127, no. 3, pp. 709–714. DOI: 10.1002/lary.26115
- Katzman R., Aronson M., Fuld P. et al. Development of dementing illnesses in an 80-year-old volunteer cohort. Annals of Neurology, 1989. Vol. 25, no. 4, pp. 317–324. DOI: 10.1002/ana.410250402
- Kimura N., Sasaki Y., Masuda T. et al. Lifestyle factors that affect cognitive function-a longitudinal objective analysis. Frontiers in Public Health, 2023. Vol. 11. Art. 1215419. DOI: 10.3389/fpubh.2023.1215419
- Krueger F., Fischer R., Heinecke A., Hagendorf H. An fMRI investigation into the neural mechanisms of spatial attentional selection in a location-based negative priming task. Brain Research, 2007. Vol. 1174, pp. 110–119. DOI: 10.1016/j.brainres.2007.08.016
- Li S.-C., Lindenberger U. Cross-level unification: a computational exploration of the link between deterioration of neurotransmitter systems and dedifferentiation of cognitive abilities in old age. In: L.-G. Nilsson, H.J. Markowitsch (Eds.). Cognitive Neuroscience of Memory, Seattle: Hogrefe & Huber, 1999. Р 103–146.
- Li S.-C., Lindenberger U., Frensch P.A. Unifying cognitive aging: From neuromodulation to representation to cognition. Neurocomputing, 2000. Vol. 32–33, pp. 879–890. DOI: 10.1016/S0925-2312(00)00256-3
- Li S.-C., Lindenberger U., Sikström, S. Aging cognition: From neuromodulation to representation. Trends in Cognitive Sciences, 2001. Vol. 5, no. 11, pp. 479–486. DOI: 10.1016/s1364-6613(00)01769-1
- Lin M.Y., Gutierrez P.R., Stone K.L. et al. Vision impairment and combined vision and hearing impairment predict cognitive and functional decline in older women. Journal of the American Geriatrics Society, 2004. Vol. 52, no. 12, pp. 1996–2002. DOI: 10.1111/j.1532-5415.2004.52554.x
- Mattay V.S., Fera F., Tessitore A. et al. Neurophysiological correlates of age-related changes in working memory capacity. Neuroscience Letters, 2006. Vol. 392, no. 1–2, pp. 32–37. doi: 10.1016/j.neulet.2005.09.025
- Miles W.R. Age and human ability. The Psychological Review, 1933. Vol. 40, pp. 99–123. DOI: 10.1037/h0075341
- Nicholls L., Amanzio M., Güntekin B., Keage H. Editorial: The cognitive ageing collection. Scientific Reports, 2024. Vol. 14, no. 1. Art. 10869. DOI: 10.1038/s41598-024-60763-7
- Oosterhuis E., Slade K., May P., Nuttall H. Toward an understanding of healthy cognitive aging: The Importance of lifestyle in cognitive reserve and the scaffolding theory of aging and cognition. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 2023. Vol. 78, no. 5, pp. 777–788. DOI: 10.1093/geronb/gbac197
- Pouget M.C., Lévy-Bencheton D., Prost M. et al. Acquired visual field defects rehabilitation: critical review and perspectives. Annals of Physical and Rehabilitation Medicine, 2012. Vol. 55, no. 1, pp. 53–74. doi: 10.1016/j.rehab.2011.05.006
- Reuter-Lorenz P., Park D. How does it STAC up? Revisiting the scaffolding theory of aging and cognition. Neuropsychology Review, 2014. Vol. 24, no. 3, pp. 355–370. DOI: 10.1007/s11065-014-9270-9
- Salthouse T.A. The processing-speed theory of adult age differences in cognition. Psychological Review, 1996. Vol. 103, no. 3, pp. 403–428. DOI: 10.1037/0033-295x.103.3.403
- Salthouse T.A. Aging and measures of processing speed. Biological Psychology, 2000. Vol. 54, no. 1–3, pp. 35–54. DOI: 10.1016/s0301-0511(00)00052-1
- Schiffman S.S., Graham B.G. Taste and smell perception affect appetite and immunity in the elderly. European Journal of Clinical Nutrition, 2000. Vol. 54. Suppl. 3, pp. S54–S63. DOI: 10.1038/sj.ejcn.1601026
- Shimizu Y. A histomorphometric study of the age-related changes of the human taste buds in circumvallate papillae. Journal of Oral Pathology & Medicine, 1997. Vol. 2, no. 1, pp. 17–24. DOI: 10.3353/omp.2.17
- Spreng R., Wojtowicz M., Grady C. Reliable differences in brain activity between young and old adults: a quantitative meta-analysis across multiple cognitive domains. Neuroscience and Biobehavioral Reviews, 2010. Vol. 34, no. 8, pp. 1178–1194. DOI: 10.1016/j.neubiorev.2010.01.009
- Stern Y., Moeller J.R., Anderson K.E. et al. Different brain networks mediate task performance in normal aging and AD: defining compensation. Neurology, 2000. Vol. 55, no. 9, pp. 1291–1297. DOI: 10.1212/wnl.55.9.1291
- Valentijn S.A., van Boxtel M.P., van Hooren S.A. et al. Change in sensory functioning predicts change in cognitive functioning: results from a 6-year follow-up in the Maastricht aging study. Journal of the American Geriatrics Society, 2005. Vol. 53, no. 3, pp. 374–380. DOI: 10.1111/j.1532-5415.2005.53152.x
- Verhaeghen P., Cerella J. Aging, executive control, and attention: a review of meta-analyses. Neuroscience & Biobehavioral Reviews, 2002. Vol. 26, no. 7, pp. 849–857. DOI: 10.1016/s0149-7634(02)00071-4
- Verhaeghen P., De Meersman L. Aging and the negative priming effect: a meta-analysis. Psychology and Aging, 1998. Vol. 13, no. 3, pp. 435–444. DOI: 10.1037//0882-7974.13.3.435
- Wehling E., Nordin S., Espeseth T. et al. Unawareness of olfactory dysfunction and its association with cognitive functioning in middle aged and old adults. Archives of Clinical Neuropsychology, 2011. Vol. 26, no. 3, pp. 260–269. DOI: 10.1093/arclin/acr019
- West R. The effects of aging on controlled attention and conflict processing in the Stroop Journal of Cognitive Neuroscience, 2004 Vol. 16, no. 1, pp. 103–113. DOI: 10.1162/089892904322755593
Information About the Authors
Metrics
Views
Total: 16
Previous month: 0
Current month: 16
Downloads
Total: 4
Previous month: 0
Current month: 4