The Function of Planning in Children with a History of Neuro-Oncological Disease

The aim of the study was to estimate the influence of radio- and chemotherapy and tumor's localization on executive functions of the prefrontal cortex. Research involved 58 children with neuro-oncological disease in anamnesis (cerebellum localization and temporal – parietal lobes localization) treated in the Morozov Children's Clinical Hospital. Also research involved 120 typically developing children. Planning was assessed using the Cambridge planning test (Stockings of Cambridge) computer battery of neuropsychological tests CANTAB (Cambridge Neuropsychological Test Automated Battery). Additionally, it is revealed that there is an adverse effect of chemotherapy and radiotherapy on executive functions in tumor of the cerebellum. Funding This work was supported by grant RFBR № 15-06-08680. Acknowledgements The authors thank neuropsychologist E.Yu. Vlasova and neurologist E.V. Andreeva for help in gathering data.

1. Badalyan L.O. Detskaya nevrologiya [Pediatric neurology] Moscow: Publ. Medpress, 2010. 608 p.
2. Burdukova Yu.A., Vlasova E.Yu., Gniteeva L.N., Andreeva E.V., Popov V.E. Vliyanie khimio- i luchevoi terapii na kognitivnoe razvitie u detei s opukholyami razlichnoi lokalizatsii [Influence of radio- and chemotherapy on cognitive development of children with brain tumor]. Psikhologicheskie Issledovaniya psystudy.ru [Psychological Studies psystudy.ru], 2015, vol. 8, no. 41, pp. 3. Available at: http://psystudy.ru/index .php/num/2015v8n41/1135-burdukova41.html (Accessed 15.11.2016) (In Russ., abstr. in Engl.)
3. Voronin N.A., Burdukova Yu.A., Gniteeva L.N., Andreeva E.V., Popov V.E., Stroganova T.A. Kognitivnoe razvitie detei s opukholyami golovnogo mozga [Cognitive development in children with brain tumors]. Voprosy Psikhologii [The Issues Relevant to Psychology], 2013, no. 6, pp. 24–37. (In Russ., abstr. in Engl.)
4. Korsakova N.K., Kalashnikova L.A., Zueva Yu.V., Pugacheva O.V. Narushenie vysshikh psikhicheskikh funktsii pri infarktakh mozzhechka [Disoders of higher mental functions in the cerebellar infarcts]. Sbornik tezisov VIII Vserossiiskogo s"ezda nevrologov (Kazan,
   21-25 maya 2001 g.) [Proceedings of the 8th All-Russian Neurology Congress]. Kazan, 2001, pp. 237–238.
5. Novikova S.I., Stroganova T.A. Planirovanie deistvii u detei 5–6 let: Vozrastnye i individual'nye razlichiya v vypolnenii testa «Londonskaya bashnya» [Action planning by
   5-6-year-olds: Age-specific and individual differences in "The Tower of London" task]. Voprosy Psikhologii [The Issues Relevant to Psychology], 2006, no. 4, pp. 36–46. (In Russ., abstr. in Engl.)
6. Aarsen F.K., Van Dongen H.R., Paquier P.F., Van Mourik M., Catsman-Berrevoets C.E. Long-term sequelae in children after cerebellar astrocytoma surgery. Neurology, 2004,
   vol. 62, no. 8, pp. 1311–1316. doi: 10.1212/01.WNL.0000120549.77188.36
7. Bull K.S., Kennedy C.R. Neurocognitive effects of CNS tumors. Handbook Clinical Neurology, 2013, vol. 112, pp. 967–972. doi: 10.1016/B978-0-444-52910-7.00017-9.
   doi: 10.1016/B978-0-444-52910-7.00017-9.
8. Diamond A. Close Interrelation of Motor Development and Cognitive Development and of the Cerebellum and Prefrontal Cortex. Child Development, 2000, vol. 71, no. 1,
   pp. 44–56.
9. Duffner P.K. Risk factors for cognitive decline in children treated for brain tumors. European Journal Pediatric Neurology, 2010, vol. 14, no. 2, pp. 106–111.
   doi: 10.1016/j.ejpn.2009.10.005
10. Koustenis E., Driever P.H., de Sonneville L., Rueckriegel S.M.  Executive function deficits in pediatric cerebellar tumor survivors. European Journal of Pediatric Neurology, 2015, vol. 20, no. 1, pp. 25–37. doi: 10.1016/j.ejpn.2015.11.001
11. Levisohn L., Cronin-Golomb A., Schmahmann J.D. Neuropsychological consequences of cerebellar tumour resection in children: cerebellar cognitive affective syndrome in a pediatric population. Brain, 2000, vol. 123, Pt 5, pp. 1041–1050.
12. Lockwood K.A., Bell T.S., Colegrove R.W.Jr. Long-term effects of cranial radiation therapy on attention functioning in survivors of childhood leukemia. Journal of Pediatric Psychology, 1999, vol. 24, no. 1, pp. 55–65.
13. Merchant T.E., Sharma S., Xiong X.P., Wu S.J., Conklin H. Effect of cerebellum radiation dosimetry on cognitive outcomes in children with infratentorial ependymoma. International Journal of Radiation Oncology Biology Physics, 2013, vol. 90, no. 3,
    pp. 547–553. doi: 10.1016/j.ijrobp.2014.06.043
14. Posner M.I., Raichle M.E. Images of mind. New York: Scientific American Library, 1994.
15. Reimers T.S., Ehrenfels S., Mortensen E.L., Schmiegelow M. Cognitive Deficits in Long-Term Survivors of Childhood Brain Tumors: Identification of Predictive Factors. Medical Pediatric Oncology, 2003, vol. 40, no. 1, pp. 326–342. doi: 10.1002/mpo.10211
16. Riva D., Giorgi C. The cerebellum contributes to higher functions during development: evidence from a series of children surgically treated for posterior fossa tumours. Brain, 2000, vol. 123, pp. 1051–1061.
17. Schmahmann J.D. Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. Journal of Neuropsychiatry Clinical Neuroscience, 2004, vol. 16, pp. 367–378. doi: 10.1176/jnp.16.3.367.
18. Schmahmann J.D., Sherman J.C. The cerebellar cognitive affective syndrome. Brain, 1998, vol. 121, pp. 561–579.